Wide geographical dissemination of the multiresistant Staphylococcus capitis NRCS-A clone in neonatal intensive-care units.
Identifieur interne : 001431 ( Main/Exploration ); précédent : 001430; suivant : 001432Wide geographical dissemination of the multiresistant Staphylococcus capitis NRCS-A clone in neonatal intensive-care units.
Auteurs : M. Butin [France] ; J-P Rasigade [France] ; P. Martins-Sim Es [France] ; H. Meugnier [France] ; H. Lemriss [Maroc] ; R V Goering [États-Unis] ; A. Kearns [Royaume-Uni] ; M A Deighton [Australie] ; O. Denis [Belgique] ; A. Ibrahimi [Maroc] ; O. Claris [France] ; F. Vandenesch [France] ; J-C Picaud [France] ; F. Laurent [France]Source :
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [ 1469-0691 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Antibactériens (pharmacologie), Australie (épidémiologie), Enfant, Enfant d'âge préscolaire, Europe (épidémiologie), Femelle, Génotype, Humains, Infection croisée (microbiologie), Infection croisée (épidémiologie), Infections à staphylocoques (microbiologie), Infections à staphylocoques (épidémiologie), Multirésistance bactérienne aux médicaments, Mâle, Nourrisson, Nouveau-né, Phylogénie, Polymorphisme de nucléotide simple, Sepsie (microbiologie), Sepsie (épidémiologie), Staphylococcus (), Staphylococcus (génétique), Staphylococcus (isolement et purification), Typage moléculaire, Unités de soins intensifs néonatals, Épidémiologie moléculaire.
- MESH :
- génétique : Staphylococcus.
- isolement et purification : Staphylococcus.
- microbiologie : Infection croisée, Infections à staphylocoques, Sepsie.
- pharmacologie : Antibactériens.
- épidémiologie : Australie, Europe, Infection croisée, Infections à staphylocoques, Sepsie.
- Adolescent, Adulte, Enfant, Enfant d'âge préscolaire, Femelle, Génotype, Humains, Multirésistance bactérienne aux médicaments, Mâle, Nourrisson, Nouveau-né, Phylogénie, Polymorphisme de nucléotide simple, Staphylococcus, Typage moléculaire, Unités de soins intensifs néonatals, Épidémiologie moléculaire.
English descriptors
- KwdEn :
- Adolescent, Adult, Anti-Bacterial Agents (pharmacology), Australia (epidemiology), Child, Child, Preschool, Cross Infection (epidemiology), Cross Infection (microbiology), Drug Resistance, Multiple, Bacterial, Europe (epidemiology), Female, Genotype, Humans, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Male, Molecular Epidemiology, Molecular Typing, Phylogeny, Polymorphism, Single Nucleotide, Sepsis (epidemiology), Sepsis (microbiology), Staphylococcal Infections (epidemiology), Staphylococcal Infections (microbiology), Staphylococcus (classification), Staphylococcus (genetics), Staphylococcus (isolation & purification).
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents.
- classification : Staphylococcus.
- epidemiology : Australia, Cross Infection, Europe, Sepsis, Staphylococcal Infections.
- genetics : Staphylococcus.
- isolation & purification : Staphylococcus.
- microbiology : Cross Infection, Sepsis, Staphylococcal Infections.
- Adolescent, Adult, Child, Child, Preschool, Drug Resistance, Multiple, Bacterial, Female, Genotype, Humans, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Male, Molecular Epidemiology, Molecular Typing, Phylogeny, Polymorphism, Single Nucleotide.
Abstract
Nosocomial late-onset sepsis represents a frequent cause of morbidity and mortality in preterm neonates. The Staphylococcus capitis clone NRCS-A has been previously described as an emerging cause of nosocomial bacteraemia in French neonatal intensive-care units (NICUs). In this study, we aimed to explore the possible unrecognized dissemination of this clone on a larger geographical scale. One hundred methicillin-resistant S. capitis strains isolated from neonates (n = 86) and adult patients (n = 14) between 2000 and 2013 in four different countries (France, Belgium, the UK, and Australia) were analysed with SmaI pulsed-field gel electrophoresis (PFGE) and dru typing. The vast majority of NICU strains showed the NRCS-A pulsotype and the dt11c type (96%). We then randomly selected 14 isolates (from neonates, n = 12, three per country; from adult patients, n = 2), considered to be a subset of representative isolates, and performed further molecular typing (SacII PFGE, SCCmec typing, and multilocus sequence typing-like analysis), confirming the clonality of the S. capitis strains isolated from neonates, despite their distant geographical origin. Whole genome single-nucleotide polymorphism-based phylogenetic analysis of five NICU isolates (from the different countries) attested to high genetic relatedness within the NRCS-A clone. Finally, all of the NRCS-A strains showed multidrug resistance (e.g. methicillin and aminoglycoside resistance, and decreased vancomycin susceptibility), with potential therapeutic implications for infected neonates. In conclusion, this study represents the first report of clonal dissemination of methicillin-resistant coagulase-negative Staphylococcus clone on a large geographical scale. Questions remain regarding the origin and means of international spread, and the reasons for this clone's apparent predilection for neonates.
DOI: 10.1016/j.cmi.2015.09.008
PubMed: 26404028
Affiliations:
- Australie, Belgique, France, Maroc, Royaume-Uni, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Grand Londres, Nebraska, Rabat-Salé-Kénitra, Rhône-Alpes, Région de Bruxelles-Capitale
- Bruxelles, Londres, Lyon, Rabat, Villeurbanne
- Université libre de Bruxelles
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Le document en format XML
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Martins-Sim Es</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Meugnier, H" sort="Meugnier, H" uniqKey="Meugnier H" first="H" last="Meugnier">H. Meugnier</name><affiliation wicri:level="3"><nlm:affiliation>International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Lemriss, H" sort="Lemriss, H" uniqKey="Lemriss H" first="H" last="Lemriss">H. Lemriss</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Biotechnology, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University of Rabat, Rabat, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Laboratory of Biotechnology, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University of Rabat, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Goering, R V" sort="Goering, R V" uniqKey="Goering R" first="R V" last="Goering">R V Goering</name><affiliation wicri:level="2"><nlm:affiliation>Creighton University, Omaha, NE, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Creighton University, Omaha, NE</wicri:regionArea><placeName><region type="state">Nebraska</region></placeName></affiliation></author><author><name sortKey="Kearns, A" sort="Kearns, A" uniqKey="Kearns A" first="A" last="Kearns">A. Kearns</name><affiliation wicri:level="3"><nlm:affiliation>Public Health England, Staphylococcus Reference Service, Colindale, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, Staphylococcus Reference Service, Colindale, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Deighton, M A" sort="Deighton, M A" uniqKey="Deighton M" first="M A" last="Deighton">M A Deighton</name><affiliation wicri:level="1"><nlm:affiliation>RMIT University, Bundoora, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>RMIT University, Bundoora, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Denis, O" sort="Denis, O" uniqKey="Denis O" first="O" last="Denis">O. Denis</name><affiliation wicri:level="4"><nlm:affiliation>Erasme Hospital, Université Libre de Bruxelles, Laboratoire de Référence MRSA, Staphylocoques, Department of Microbiology, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Erasme Hospital, Université Libre de Bruxelles, Laboratoire de Référence MRSA, Staphylocoques, Department of Microbiology, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Ibrahimi, A" sort="Ibrahimi, A" uniqKey="Ibrahimi A" first="A" last="Ibrahimi">A. Ibrahimi</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Biotechnology, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University of Rabat, Rabat, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Laboratory of Biotechnology, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University of Rabat, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Claris, O" sort="Claris, O" uniqKey="Claris O" first="O" last="Claris">O. Claris</name><affiliation wicri:level="1"><nlm:affiliation>Claude Bernard University Lyon 1, Villeurbanne, France; Neonatal Intensive Care Unit, Eastern Hospital Group, Hospices Civils de Lyon, Bron, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Claude Bernard University Lyon 1, Villeurbanne, France; Neonatal Intensive Care Unit, Eastern Hospital Group, Hospices Civils de Lyon, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Vandenesch, F" sort="Vandenesch, F" uniqKey="Vandenesch F" first="F" last="Vandenesch">F. Vandenesch</name><affiliation wicri:level="3"><nlm:affiliation>International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, Villeurbanne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, Villeurbanne</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Villeurbanne</settlement><settlement type="city" wicri:auto="agglo">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Picaud, J C" sort="Picaud, J C" uniqKey="Picaud J" first="J-C" last="Picaud">J-C Picaud</name><affiliation wicri:level="3"><nlm:affiliation>Claude Bernard University Lyon 1, Villeurbanne, France; Neonatal Intensive Care Unit, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Claude Bernard University Lyon 1, Villeurbanne, France; Neonatal Intensive Care Unit, Northern Hospital Group, Hospices Civils de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Laurent, F" sort="Laurent, F" uniqKey="Laurent F" first="F" last="Laurent">F. Laurent</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, Villeurbanne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, Villeurbanne</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Villeurbanne</settlement><settlement type="city" wicri:auto="agglo">Lyon</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26404028</idno><idno type="pmid">26404028</idno><idno type="doi">10.1016/j.cmi.2015.09.008</idno><idno type="wicri:Area/PubMed/Corpus">002552</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002552</idno><idno type="wicri:Area/PubMed/Curation">002484</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002484</idno><idno type="wicri:Area/PubMed/Checkpoint">002484</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002484</idno><idno type="wicri:Area/Ncbi/Merge">002B14</idno><idno type="wicri:Area/Ncbi/Curation">002B14</idno><idno type="wicri:Area/Ncbi/Checkpoint">002B14</idno><idno type="wicri:Area/Main/Merge">001426</idno><idno type="wicri:Area/Main/Curation">001431</idno><idno type="wicri:Area/Main/Exploration">001431</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Wide geographical dissemination of the multiresistant Staphylococcus capitis NRCS-A clone in neonatal intensive-care units.</title><author><name sortKey="Butin, M" sort="Butin, M" uniqKey="Butin M" first="M" last="Butin">M. Butin</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France. Electronic address: marine.butin@chu-lyon.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Rasigade, J P" sort="Rasigade, J P" uniqKey="Rasigade J" first="J-P" last="Rasigade">J-P Rasigade</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, Villeurbanne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, Villeurbanne</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Villeurbanne</settlement><settlement type="city" wicri:auto="agglo">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Martins Sim Es, P" sort="Martins Sim Es, P" uniqKey="Martins Sim Es P" first="P" last="Martins-Sim Es">P. Martins-Sim Es</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Meugnier, H" sort="Meugnier, H" uniqKey="Meugnier H" first="H" last="Meugnier">H. Meugnier</name><affiliation wicri:level="3"><nlm:affiliation>International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Lemriss, H" sort="Lemriss, H" uniqKey="Lemriss H" first="H" last="Lemriss">H. Lemriss</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Biotechnology, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University of Rabat, Rabat, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Laboratory of Biotechnology, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University of Rabat, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Goering, R V" sort="Goering, R V" uniqKey="Goering R" first="R V" last="Goering">R V Goering</name><affiliation wicri:level="2"><nlm:affiliation>Creighton University, Omaha, NE, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Creighton University, Omaha, NE</wicri:regionArea><placeName><region type="state">Nebraska</region></placeName></affiliation></author><author><name sortKey="Kearns, A" sort="Kearns, A" uniqKey="Kearns A" first="A" last="Kearns">A. Kearns</name><affiliation wicri:level="3"><nlm:affiliation>Public Health England, Staphylococcus Reference Service, Colindale, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, Staphylococcus Reference Service, Colindale, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Deighton, M A" sort="Deighton, M A" uniqKey="Deighton M" first="M A" last="Deighton">M A Deighton</name><affiliation wicri:level="1"><nlm:affiliation>RMIT University, Bundoora, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>RMIT University, Bundoora, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Denis, O" sort="Denis, O" uniqKey="Denis O" first="O" last="Denis">O. Denis</name><affiliation wicri:level="4"><nlm:affiliation>Erasme Hospital, Université Libre de Bruxelles, Laboratoire de Référence MRSA, Staphylocoques, Department of Microbiology, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Erasme Hospital, Université Libre de Bruxelles, Laboratoire de Référence MRSA, Staphylocoques, Department of Microbiology, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Ibrahimi, A" sort="Ibrahimi, A" uniqKey="Ibrahimi A" first="A" last="Ibrahimi">A. Ibrahimi</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Biotechnology, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University of Rabat, Rabat, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Laboratory of Biotechnology, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University of Rabat, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Claris, O" sort="Claris, O" uniqKey="Claris O" first="O" last="Claris">O. Claris</name><affiliation wicri:level="1"><nlm:affiliation>Claude Bernard University Lyon 1, Villeurbanne, France; Neonatal Intensive Care Unit, Eastern Hospital Group, Hospices Civils de Lyon, Bron, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Claude Bernard University Lyon 1, Villeurbanne, France; Neonatal Intensive Care Unit, Eastern Hospital Group, Hospices Civils de Lyon, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Vandenesch, F" sort="Vandenesch, F" uniqKey="Vandenesch F" first="F" last="Vandenesch">F. Vandenesch</name><affiliation wicri:level="3"><nlm:affiliation>International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, Villeurbanne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, Villeurbanne</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Villeurbanne</settlement><settlement type="city" wicri:auto="agglo">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Picaud, J C" sort="Picaud, J C" uniqKey="Picaud J" first="J-C" last="Picaud">J-C Picaud</name><affiliation wicri:level="3"><nlm:affiliation>Claude Bernard University Lyon 1, Villeurbanne, France; Neonatal Intensive Care Unit, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Claude Bernard University Lyon 1, Villeurbanne, France; Neonatal Intensive Care Unit, Northern Hospital Group, Hospices Civils de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Laurent, F" sort="Laurent, F" uniqKey="Laurent F" first="F" last="Laurent">F. Laurent</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, Villeurbanne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, ENS de Lyon, Lyon, France; National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, Villeurbanne</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Villeurbanne</settlement><settlement type="city" wicri:auto="agglo">Lyon</settlement></placeName></affiliation></author></analytic><series><title level="j">Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</title><idno type="eISSN">1469-0691</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Australia (epidemiology)</term><term>Child</term><term>Child, Preschool</term><term>Cross Infection (epidemiology)</term><term>Cross Infection (microbiology)</term><term>Drug Resistance, Multiple, Bacterial</term><term>Europe (epidemiology)</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Intensive Care Units, Neonatal</term><term>Male</term><term>Molecular Epidemiology</term><term>Molecular Typing</term><term>Phylogeny</term><term>Polymorphism, Single Nucleotide</term><term>Sepsis (epidemiology)</term><term>Sepsis (microbiology)</term><term>Staphylococcal Infections (epidemiology)</term><term>Staphylococcal Infections (microbiology)</term><term>Staphylococcus (classification)</term><term>Staphylococcus (genetics)</term><term>Staphylococcus (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Antibactériens (pharmacologie)</term><term>Australie (épidémiologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Europe (épidémiologie)</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Infection croisée (microbiologie)</term><term>Infection croisée (épidémiologie)</term><term>Infections à staphylocoques (microbiologie)</term><term>Infections à staphylocoques (épidémiologie)</term><term>Multirésistance bactérienne aux médicaments</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Phylogénie</term><term>Polymorphisme de nucléotide simple</term><term>Sepsie (microbiologie)</term><term>Sepsie (épidémiologie)</term><term>Staphylococcus ()</term><term>Staphylococcus (génétique)</term><term>Staphylococcus (isolement et purification)</term><term>Typage moléculaire</term><term>Unités de soins intensifs néonatals</term><term>Épidémiologie moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Staphylococcus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Australia</term><term>Cross Infection</term><term>Europe</term><term>Sepsis</term><term>Staphylococcal Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Staphylococcus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Staphylococcus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Staphylococcus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Staphylococcus</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infection croisée</term><term>Infections à staphylocoques</term><term>Sepsie</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Cross Infection</term><term>Sepsis</term><term>Staphylococcal Infections</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibactériens</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Australie</term><term>Europe</term><term>Infection croisée</term><term>Infections à staphylocoques</term><term>Sepsie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Child, Preschool</term><term>Drug Resistance, Multiple, Bacterial</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Intensive Care Units, Neonatal</term><term>Male</term><term>Molecular Epidemiology</term><term>Molecular Typing</term><term>Phylogeny</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Multirésistance bactérienne aux médicaments</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Phylogénie</term><term>Polymorphisme de nucléotide simple</term><term>Staphylococcus</term><term>Typage moléculaire</term><term>Unités de soins intensifs néonatals</term><term>Épidémiologie moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nosocomial late-onset sepsis represents a frequent cause of morbidity and mortality in preterm neonates. The Staphylococcus capitis clone NRCS-A has been previously described as an emerging cause of nosocomial bacteraemia in French neonatal intensive-care units (NICUs). In this study, we aimed to explore the possible unrecognized dissemination of this clone on a larger geographical scale. One hundred methicillin-resistant S. capitis strains isolated from neonates (n = 86) and adult patients (n = 14) between 2000 and 2013 in four different countries (France, Belgium, the UK, and Australia) were analysed with SmaI pulsed-field gel electrophoresis (PFGE) and dru typing. The vast majority of NICU strains showed the NRCS-A pulsotype and the dt11c type (96%). We then randomly selected 14 isolates (from neonates, n = 12, three per country; from adult patients, n = 2), considered to be a subset of representative isolates, and performed further molecular typing (SacII PFGE, SCCmec typing, and multilocus sequence typing-like analysis), confirming the clonality of the S. capitis strains isolated from neonates, despite their distant geographical origin. Whole genome single-nucleotide polymorphism-based phylogenetic analysis of five NICU isolates (from the different countries) attested to high genetic relatedness within the NRCS-A clone. Finally, all of the NRCS-A strains showed multidrug resistance (e.g. methicillin and aminoglycoside resistance, and decreased vancomycin susceptibility), with potential therapeutic implications for infected neonates. In conclusion, this study represents the first report of clonal dissemination of methicillin-resistant coagulase-negative Staphylococcus clone on a large geographical scale. Questions remain regarding the origin and means of international spread, and the reasons for this clone's apparent predilection for neonates.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>France</li><li>Maroc</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Grand Londres</li><li>Nebraska</li><li>Rabat-Salé-Kénitra</li><li>Rhône-Alpes</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li><li>Londres</li><li>Lyon</li><li>Rabat</li><li>Villeurbanne</li></settlement><orgName><li>Université libre de Bruxelles</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Butin, M" sort="Butin, M" uniqKey="Butin M" first="M" last="Butin">M. Butin</name></region><name sortKey="Claris, O" sort="Claris, O" uniqKey="Claris O" first="O" last="Claris">O. Claris</name><name sortKey="Laurent, F" sort="Laurent, F" uniqKey="Laurent F" first="F" last="Laurent">F. Laurent</name><name sortKey="Martins Sim Es, P" sort="Martins Sim Es, P" uniqKey="Martins Sim Es P" first="P" last="Martins-Sim Es">P. Martins-Sim Es</name><name sortKey="Meugnier, H" sort="Meugnier, H" uniqKey="Meugnier H" first="H" last="Meugnier">H. Meugnier</name><name sortKey="Picaud, J C" sort="Picaud, J C" uniqKey="Picaud J" first="J-C" last="Picaud">J-C Picaud</name><name sortKey="Rasigade, J P" sort="Rasigade, J P" uniqKey="Rasigade J" first="J-P" last="Rasigade">J-P Rasigade</name><name sortKey="Vandenesch, F" sort="Vandenesch, F" uniqKey="Vandenesch F" first="F" last="Vandenesch">F. Vandenesch</name></country><country name="Maroc"><region name="Rabat-Salé-Kénitra"><name sortKey="Lemriss, H" sort="Lemriss, H" uniqKey="Lemriss H" first="H" last="Lemriss">H. Lemriss</name></region><name sortKey="Ibrahimi, A" sort="Ibrahimi, A" uniqKey="Ibrahimi A" first="A" last="Ibrahimi">A. Ibrahimi</name></country><country name="États-Unis"><region name="Nebraska"><name sortKey="Goering, R V" sort="Goering, R V" uniqKey="Goering R" first="R V" last="Goering">R V Goering</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kearns, A" sort="Kearns, A" uniqKey="Kearns A" first="A" last="Kearns">A. Kearns</name></region></country><country name="Australie"><noRegion><name sortKey="Deighton, M A" sort="Deighton, M A" uniqKey="Deighton M" first="M A" last="Deighton">M A Deighton</name></noRegion></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Denis, O" sort="Denis, O" uniqKey="Denis O" first="O" last="Denis">O. Denis</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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